Annual incidence (%) of first time H pylori infection in comparable studies
| Author (ref) | Year of publication | Country | H pylori detection method | Number | Ages (y) | Number of seroconverters | Observation period | Number of observation years | Annual incidence (%) and 95% CIs | Comments |
| Parsonnet13 | 1992 | US | IgG ELISA | 341 | 30–50 | 11 | 1969 to 1987/88 | 8.5 | 0.49 (0.3, 0.9)4-150 | The antigen was a pool of sonicated isolates ofH pylori. Sensitivity and specificity exceeded 95% |
| Kuipers14 | 1993 | Netherlands | IgG ELISA | 115 | 15–80 | 2 | 1979/83 to 1992 | 11.5 | 0.30 (0.04, 1.08) | |
| Veldhuyzen van Zanten15 † | 1992 | Canada | IgG and IgA ELISA | 175 | 18–71 | 1 | — | 2–3 | 0.0024 | IgG and IgA antibodies were measured with flow cytometric immunofluorescent assay. Only published in abstract form. |
| Cullen16 | 1990 | Australia | IgG ELISA | 141 | 20–65 | 6 | 1969/1978/1990 | 21 | 0.33 (0.08, 0.59)4-150 | Acid-glycine extracted antigen. Sensitivity 86%, specificity 96%. |
| Banatvala17 | 1994 | Japan | IgG ELISA | 417 | — | 7 | 1980 to 1989/90 | 10 | 1.1 | Only published in abstract form |
| Sipponen18 | 1996 | Finland | IgG and IgA ELISA, histology | 181 | 53 (±2) | 12 | 1974/76 to 1991 | 15 | 0.44 (0.23, 0.80) | Participants were endoscoped but not bled at study entry. Acid-glycine extracted antigen. Seroconversion rates increased with age. |
| Rosenstock‡ | 2000 | Denmark | IgG ELISA | 2,527 | 30–72 | 14 | 1982/83 to 1994/95 | 11 | 0.01 (0.04, 0.14) | Normal population, LMW antigen, sensitivity 98.5%, specificity 54% |
| Valle38 | 1996 | Finland | Histology | 102 | 15–55 | 2 | 1952 to 1983 | 32 | 0.4 (0.04, 1.0)† | Outpatients with dyspepsia.H pylori infection status at study entry was assessed by blind suction biopsy |
↵4-150 Annual incidence per patient year. †The observation period was not reported. ‡Annual incidence proportion in per cent for both sexes.