RT Journal Article SR Electronic T1 P1-122 Frailty and incidence of disability in activities of daily living in elderly JF Journal of Epidemiology and Community Health JO J Epidemiol Community Health FD BMJ Publishing Group Ltd SP A100 OP A101 DO 10.1136/jech.2011.142976d.15 VO 65 IS Suppl 1 A1 L P Corona A1 T S Alexandre A1 D P Nunes A1 J L F Santos A1 Y A de Oliveira Duarte A1 M L Lebrao YR 2011 UL http://jech.bmj.com/content/65/Suppl_1/A100.4.abstract AB Introduction Frailty is known as a factor associated with risk of disability in elderly.Objectives To examine the association between frailty status and incidence of activities of daily living (ADL) disability in elderly.Methods Data comes from a longitudinal survey—SABE (Health, Well-being and Ageing), which began in 2000 with a multistage clustered sample of 2143 people aged ≥60 years-old in Sao Paulo-Brazil. Frailty components (Fried's model) were included in 2006, during the second wave (n=1115 re-interviewed). In 2006, used here as baseline, a subsample of 688 persons aged ≥75 years was followed-up, in 2 rounds (2008–2009). Measures included: frailty status in baseline; incidence of ADL disability (baseline-2009). We tested two adjusted logistic multiple regression models. Inferences were weighted to account for sample design.Results In 2006, 389 elderly had no ADL limitation. In 2009, after excluding those who scored <19 in Mini-Mental State Exam, ADL were analysed in a sample of 242 elderly. The disability incidence was 91.5/1000 person-years in robust, 118.6/1000 person-years in pre-frail, and 223.2/1000 person-years in frail elderly. Frailty is associated to the risk of developing disability (OR=3.32; p=0.015). In model 1, adjusted for age, sex and education, frailty remains significantly associated (OR=2.54; p=0.045). In model 2, after adding depression, falls, BMI, and mobility limitation, frailty lost significance, but still shows risk (OR=2.61; p=0.066).Conclusions Incidence rate of ADL limitation was greater in frail elderly, but other factors, as depression and falls, are also important and should be considered.