Several epidemiological studies have produced longitudinal data identifying fibrinogen as a major cardiovascular risk factor. Cross-sectional results show strong associations between fibrinogen and a variety of demographic variables, cardiovascular risk factors, or diseases. Clinical cohort studies demonstrate that fibrinogen might also be a risk factor for the sequelae of cardiovascular disease. Knowledge about the determinants of the plasma level of fibrinogen in health and disease is as yet incomplete. Understanding of the mechanisms leading to the atherothrombogenic action of fibrinogen is also fragmentary. Fibrinogen strongly affects blood coagulation, blood rheology and platelet aggregation; in addition fibrinogen and its metabolites have direct effects on the vascular wall. Finally, fibrinogen is a prominent acute phase protein. All of these phenomena might provide some insight into the pathophysiological mechanisms involved. It is concluded that fibrinogen represents a major, independent risk factor that should now be included into the cardiovascular risk profile.