Original reportThe Logic for a Conception-to-Death Cohort Study
Section snippets
Selected Abbreviations and Acronyms
AIDS = Acquired Immune Deficiency Syndrome
DNA = deoxyribonucleic acid
ECA = economic catchment area
HIV = Human Immunodeficiency Virus
NIH = National Institutes of Health
RNA = ribonucleic acid
Conclusion
When do diseases begin? How do genes and environment interact over the life course to influence the occurrence of diseases? How do diseases, and the etiologic processes underlying them, affect one another? How do we study these questions when the causal period is approaching that of the human life span itself? Reviewing these questions, it seems curious or even paradoxical that we have not already begun such a study. We have studied thousands of generations of fruit flies, for example; and
Acknowledgements
The paper was prepared for the Rema Lapouse Award Lecture, American Public Health Association, Boston, Massachusetts, November 2000. Preparation was greatly aided by discussion with the following persons, who have no responsibility for the contents: James Anthony, Harout Armenian, Leon Gordis, Janet Hardy, Larry Mayer, Alvaro Muñoz, Gerald Nestadt, Peter Scheidt, and Peter Zandi. Salary support for this work came from NIMH grants MH47447 and MH53188.
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