ReviewDevelopmental neurotoxicity of PCBs in humans: What do we know and where do we go from here?
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Neurochemical effects of halogenated organic compounds: Possible adverse outcome pathways and structure–activity relationships
2023, Advances in NeurotoxicologyReview of rodent models of attention deficit hyperactivity disorder
2022, Neuroscience and Biobehavioral ReviewsMaternal exposure to a human based mixture of persistent organic pollutants (POPs) affect gene expression related to brain function in mice offspring hippocampus
2021, ChemosphereCitation Excerpt :The results on behavioural outcomes are to some extent contradictory to results obtained in human observational studies. Adverse neurodevelopmental effects are reported after exposure to OC compounds (Urabe et al., 1979; Kilburn and Thornton, 1995; Schantz, 1996; Winneke et al., 1998; Ribas-Fito et al., 2003, Ribas-Fito et al., 2007; Eskenazi et al., 2006; Korrick and Sagiv, 2008; Park et al., 2010; Torres-Sanchez et al., 2013), PCBs (Fein et al., 1984; Rogan et al., 1986; Gladen et al., 1988; Tilson et al., 1990; Jacobson and Jacobson, 1996; Seegal, 1996; Longnecker et al., 1997), and BDEs (Roze et al., 2009; Herbstman et al., 2010; Gascon et al., 2011; Cowell et al., 2015). The epidemiological evidence for adverse neurodevelopmental effects of PFASs seems less convincing compared to chlorinated and brominated POPs, and some results are contradictory.
Gut microbiome: An intermediary to neurotoxicity
2019, NeuroToxicologyCitation Excerpt :In humans, epidemiological studies showed a positive link between developmental PCB exposure and neurological deficits in infants and children (Korrick and Sagiv, 2008; Schantz, 1996; Winneke, 2011). Symptoms associated with PCB neurotoxicity include decreased motor and cognitive skills in newborns, greater incidence of behavioral problems and lower IQ scores in children, and lower cognitive functioning in older adults (Przybyla et al., 2017; Ribas-Fito et al., 2001; Schantz, 1996). Developmental neurotoxicity following PCB exposure has also been observed in laboratory animals including mouse and rat pups, as well as chicken embryos (Kania-Korwel et al., 2017; Roelens et al., 2005; Yang et al., 2009) and in neuronal cell cultures (Lyng and Seegal, 2008; Lyng et al., 2007).