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The impact of bivalent HPV vaccine on cervical intraepithelial neoplasia by deprivation in Scotland: reducing the gap
  1. Ross L Cameron1,
  2. Kimberley Kavanagh2,
  3. D Cameron Watt1,
  4. Chris Robertson1,2,3,
  5. Kate Cuschieri4,
  6. Syed Ahmed1,
  7. Kevin G Pollock1
  1. 1Health Protection Scotland, Glasgow, UK
  2. 2Department of Mathematics and Statistics, University of Strathclyde, Glasgow, UK
  3. 3International Prevention Research Institute, Lyon, France
  4. 4Scottish Human Papillomavirus Reference Laboratory, Edinburgh, UK
  1. Correspondence to Ross L Cameron, Health Protection Scotland,Meridian Court,5 Cadogan Street,Glasgow,G2 6QE,UK; ross.cameron{at}nhs.net

Abstract

Background Cervical cancer disproportionately affects women from lower socioeconomic backgrounds. A human papillomavirus (HPV) vaccination programme was introduced in Scotland in 2008 with uptake being lower and inequitable in a catch-up cohort run for the first three years of the programme compared with the routine programme. The socioeconomic differences in vaccine uptake have the potential to further increase the inequality gap in regards to cervical disease.

Methods Vaccination status was linked to demographic, cytological and colposcopic data, which are routinely collected by the Scottish HPV surveillance system. Incidence rates and relative risk of cervical intraepithelial neoplasia (CIN) 1, 2 and 3 in unvaccinated and vaccinated women were stratified by birth year and deprivation status using Poisson regression.

Results Women who received three doses of HPV vaccine have significantly decreased risk of CIN 1, 2 and 3. Vaccine effectiveness was greater in those women from the most deprived backgrounds against CIN 2 and 3 lesions. Compared with the most deprived, unvaccinated women, the relative risk of CIN 3 in fully vaccinated women in the same deprivation group was 0.29 (95% CI 0.2 to 0.43) compared with 0.62 (95% CI 0.4 to 0.97) in vaccinated women in the least-deprived group.

Conclusions The HPV vaccine is associated with significant reductions in both low-grade and high-grade CIN for all deprivation categories. However, the effect on high-grade disease was most profound in the most-deprived women. These data are welcoming and allay the concern that inequalities in cervical cancer may persist or increase following the introduction of the vaccine in Scotland.

  • vaccination
  • cancer: cervix
  • sexually trans dis
  • social inequalities
  • health inequalities

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Footnotes

  • Contributors SA is the clinical lead for the work. KGP and RLC conceived the original idea for the work. Testing of samples and data collection was coordinated by KC. Data collation, management and linkage were performed by DCW. Data analysis and interpretation was undertaken by RLC, KK and CR. Drafting of the article was undertaken by RLC and all authors critically revised the article and approved the final manuscript.

  • Competing interests KGP has received travel subsistence for the International Human Papillomavirus conference. KC has received grants from Cepheid, Gene First and Euroimmun outside of the submitted work.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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