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High hepatitis C virus prevalence and incidence in a community cohort of young heroin injectors in a context of extensive harm reduction programmes
  1. Fernando Vallejo1,2,
  2. Gregorio Barrio3,
  3. M Teresa Brugal2,4,5,
  4. Jose Pulido1,2,
  5. Carlos Toro6,
  6. Luis Sordo1,2,
  7. Albert Espelt4,5,7,
  8. María J Bravo1,2,
  9. the Itinere Project Group
  1. Correspondence to Dr Gregorio Barrio, Escuela Nacional de Sanidad, Instituto de Salud Carlos III, Madrid, Avda Monforte de Lemos, 5, Madrid 28029, Spain; gbarrio{at}isciii.es

Abstract

Background Cohort studies on hepatitis C virus (HCV) among drug injectors are scarcer than studies on HIV. Combined harm reduction interventions (HRIs) can prevent HCV infection. Spain has a medium–high coverage of HRIs.

Methods 513 young heroin users who injected drugs in the past 12 months (recent injectors) were street-recruited in 2001–2003 and followed until 2006 in three Spanish cities; 137 were anti-HCV seronegative, 77 of whom had ≥1 follow-up visit. Dried blood spots were tested for anti-HCV. HCV incidence and predictors of infection were estimated using Poisson models.

Results At baseline, 73% were anti-HCV positive. Overall incidence (n=77) of HCV seroconversion was 39.8/100 person-years (py) (95% CI 28.7 to 53.8). Excluding non-injectors during follow-up from the analysis (n=57), HCV incidence was 52.9/100 py (95% CI 37.4 to 72.5). Injecting at least weekly (incidence rate ratio (IRR)=5.2 (95% CI 2.5 to 11.1)) and having ≥2 sexual partners (IRR=2.2 (95% CI 1.1 to 4.7)) were independent predictors of HCV seroconversion; drug-injection history <2 years was marginally associated (IRR=2.4 (95% CI 0.9 to 4.7)). HCV incidence may have been underestimated due to differential attrition.

Conclusions Despite fairly high HRI coverage among Spanish drug injectors, a distressingly high incidence of HCV in a context of high HCV prevalence was found among young heroin injectors.

  • HEPATITIS
  • EPIDEMIOLOGY
  • SUBSTANCE ABUSE

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