Article Text

other Versions

PDF
Association of a lifestyle index with MRI-determined liver fat content in a general population study
  1. Manja Koch1,2,
  2. Jan Borggrefe3,
  3. Sabrina Schlesinger1,2,
  4. Janett Barbaresko2,4,
  5. Godo Groth5,
  6. Gunnar Jacobs6,
  7. Wolfgang Lieb1,
  8. Matthias Laudes7,
  9. Manfred J Müller8,
  10. Anja Bosy-Westphal9,
  11. Martin Heller5,
  12. Ute Nöthlings2,4
  1. 1Institute of Epidemiology, Christian-Albrechts University Kiel, Kiel, Germany
  2. 2Institute of Experimental Medicine, Christian-Albrechts University Kiel, Kiel, Germany
  3. 3Department of Radiology, University of Cologne, Cologne, Germany
  4. 4Nutritional Epidemiology, Department of Nutrition and Food Science, Rheinische Friedrich-Wilhelms-University Bonn, Bonn, Germany
  5. 5Clinic for Diagnostic Radiology, University Medical Center Schleswig-Holstein, Kiel, Germany
  6. 6PopGen Biobank, University Medical Center Schleswig-Holstein, Kiel, Germany
  7. 7Institute of Internal Medicine I, Christian-Albrechts University Kiel, Kiel, Germany
  8. 8Institute of Human Nutrition and Food Science, Christian-Albrechts University Kiel, Kiel, Germany
  9. 9Institute of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany
  1. Correspondence to Manja Koch, Institute of Epidemiology, Christian-Albrechts University Kiel, Campus Universitätsklinikum Schleswig-Holstein, Arnold-Heller-Straße 3, Haus 1, Kiel D-24105, Germany; manja.koch{at}epi.uni-kiel.de

Abstract

Background In prior studies, lifestyle indices were associated with numerous disease end points, but the association with fatty liver disease (FLD), a key correlate of cardiometabolic risk, is unknown. The aim was to investigate associations between a lifestyle index with liver fat content.

Methods Liver fat was quantified by MRI as liver signal intensity (LSI) in 354 individuals selected from a population-based cohort from Germany. Exposure to favourable lifestyle factors was quantified using an additive score with each factor modelled as a dichotomous trait. Favourable lifestyle factors were defined as waist circumference below 102 (men) or 88 cm (women), physical activity ≥3.5 h/week, never-smoking and a favourable dietary pattern, which was derived to explain liver fat variation. In a cross-sectional study, multivariable adjusted linear and logistic regression was applied to investigate the association between the lifestyle index (range 0–4, exposure) and LSI (modelled as a continuous trait or dichotomised as a FLD indicator variable, respectively).

Results Individuals with four favourable lifestyle factors (n=9%) had lower LSI values (ß −0.40; 95% CI −0.61 to −0.19) and a lower OR (0.09; 95% CI 0.03 to 0.30) for FLD compared with individuals with zero favourable lifestyle factors (n=10%).

Conclusions A healthy lifestyle pattern was associated with less liver fat. Prospective studies are warranted.

  • Epidemiology of chronic non communicable diseases
  • LIFESTYLE
  • NUTRITION
  • PHYSICAL ACTIVITY
  • OBESITY

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.