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Opportunity for catch-up HPV vaccination in young women after first delivery
  1. Cristina H Rama1,
  2. Luisa L Villa2,
  3. Sonia Pagliusi3,
  4. Maria A Andreoli2,
  5. Maria C Costa2,
  6. Patricia Thomann4,
  7. Venâncio A F Alves5,
  8. Adhemar Longatto-Filho6,
  9. José Eluf-Neto5
  1. 1 Hospital Maternidade Leonor Mendes de Barros and Universidade de São Paulo, Brazil;
  2. 2 Ludwig Institute for Cancer Research, São Paulo, Brazil;
  3. 3 Ludwig Institute for Cancer Research, Lausanne, Switzerland;
  4. 4 Qiagen do Brasil, São Paulo, Brazil;
  5. 5 Universidade de São Paulo, Brazil;
  6. 6 Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho,, Brazil
  1. * Corresponding author; email: crisrama{at}usp.br

Abstract

Background: Early age at first delivery has been identified as a risk factor for high-risk HPV types infection and cervical cancer development.

Methods: This cross-sectional study was carried out in a large public maternity in Sao Paulo, Brazil. During June 2006 to February 2007, 301 women aged 15-24 years who gave birth to their first child were recruited between 43 and 60 days after delivery. Detection of HPV DNA in cervical specimens was performed using a standardized polymerase chain reaction (PCR) protocol with PGMY09/11 primers. The association of selected factors with HPV infection was assessed by using Generalized Linear Model.

Results: Any HPV DNA was detected in 58.5% (95% confidence interval [CI], 52.7%-64.0%) of the enrolled young women. Most common types of HPV found were: HPV16, HPV51, HPV52, HPV58 and HPV71. The overall prevalence of HPV types targeted by the HPV prophylactic vaccines was: HPV16 -12.0%, HPV18 -2.3% and HPV 6+11-4.3%. In the multivariate analysis, only age (inversely, P for trend=0.02) and smoking habits were independently associated with HPV infection.

Conclusions: Our findings show that these young primiparous women had high cervical HPV prevalence, suggesting that this is a high risk group for cervical cancer development. Nevertheless, 17.3% were positive to any of the four HPV types included in HPV vaccines (HPV6, 11, 16 or 18), with 13.3% positive for HPV 16 or 18, and only 1.0% of them had both vaccine related oncogenic HPV types. Thus, young primiparous women could benefit from catch-up HPV vaccination programs.

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