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Tuberculosis recurrence and its associated risk factors among successfully treated patients
  1. Juan-Pablo Millet1,
  2. Angels Orcau2,
  3. Patricia García de Olalla2,
  4. Martí Casals2,
  5. Cristina Rius2,
  6. Joan A Cayla2
  1. 1 Public Health Agency of Barcelona, Spain;
  2. 2 Epidemiology Service, Public Health Agency of Barcelona, Spain
  1. E-mail: jmillet{at}


Little is known about recurrent tuberculosis (TB) in developed countries. The objective of this study was to determine the probability of TB recurrence and the associated risk factors among cured patients in a city with moderate TB incidence.

A population-based retrospective longitudinal study was carried out in Barcelona, Spain. All patients with culture-confirmed TB and drug susceptibility testing were included between 1995 and 1997 and followed until December 2005. We defined recurrence as a new TB event after considered cured and remaining free of the disease for a minimum of one year. Kaplan-Meier and Cox regression were used in the statistical analysis. Hazard ratio (HR) with 95% confidence intervals (CI) were calculated.

Among the 681 patients studied, we observed 29 recurrences (recurrence rate: 0.53/100 person-years of follow-up). The mean of TB incidence in Barcelona from 1995 to 2005 was 36.25 cases per 100,000 inhabitants. The incidence of recurrence was 14.6 times higher in the cohort than the incidence of a first TB episode in the general population. The factors associated with recurrence at bivariate level were: male, immigrant, intravenous drug users (IDU), HIV, smoking, alcohol, prison, and patients with both pulmonary and extrapulmonary TB. At multivariate level, only immigrants (HR= 3.2; CI:1.2-9), IDU (HR= 2.9; CI:1.3-6.4) and male (HR= 4.3; CI:1.3-14.6) were associated.

Having TB in the past is a risk factor for developing TB. Social policies must be implemented in populations at risk of recurrence, especially in immigrants and IDUs.

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