IS THERE AN ASSOCIATION BETWEEN BODY MASS INDEX AND MIGRAINE HEADACHES WITHIN THE CANADIAN POPULATION?
Introduction Obesity (a body mass index ≥30 kg/m2) and migraine headaches are both chronic conditions that have become increasingly common within the Canadian population. Increasing body mass index (BMI) is associated with increased frequency and severity of migraine headaches, but not its prevalence, such that increasing BMI leads to greater disability by exacerbating migraine symptoms among migraneurs. The association between increasing BMI and the prevalence of migraine headaches, however, has provided inconsistent findings. There is uncertainty as to whether there is an association between increasing BMI and an individual's risk of developing and having this condition. Some studies have found that there is an association, whereas other studies have dismissed such a relationship. There has been little to no Canadian studies conducted to determine the association between increasing BMI and the prevalence of migraines, and the Canadian Community Health Survey (CCHS) dataset has not been used as a source population.
Objective To investigate whether increasing BMI (underweight, normal, overweight, obese) was significantly associated with a linear dose-response trend in the prevalence of migraine headaches. It is hypothesized that compared with normal weight, increasing BMI would result in a larger prevalence.
Methods A sample population of 113 235 subjects from the 2007–2008 cross-sectional CCHS, Cycle 4.1 was used. Subjects included those who had responded to questions regarding self-reported height, weight and migraine status. Subjects less than 18 years of age, and those who were pregnant, were excluded. Log binomial modelling was used to derive unadjusted and adjusted prevalence ratio (PR) estimates, with their corresponding 95% CI. Population weights and average design effects were incorporated to adjust for the effects of complex survey designs.
Results When adjusting for covariates compared with normal weight, the PR for migraines was highest and significant only among the obese, 1.19 (95% CI 1.12 to 1.27), followed by underweight which was not significant, 1.09 (95% CI 0.97 to 1.23), and overweight which was marginally significant, 1.06 (95% CI 1.00 to 1.12).
Conclusions Obese and overweight BMI were significantly associated with increased prevalence of migraine headaches. Although a U-shaped pattern was observed with obese and underweight at the extremes, when addressing the non-significant PR estimates for underweight, a resulting linear dose-response trend was present, thus, resulting in the obese having the highest PR followed by overweight and normal weight. Small samples of underweight subjects, various biases, and/or an actual plausible mechanism for underweight and migraine prevalence could have accounted for the high PR estimates for underweight. Additional studies to verify results are warranted.