J Epidemiol Community Health 67:e1 doi:10.1136/jech-2013-202386.10
  • CSEB 2012 Abstracts selected for publication
  • 10


  1. Kristen Reilly
  1. Interdisciplinary School of Health Science, Faculty of Health Science, University of Ottawa


Objective To determine if there are disparities in survival outcomes in African–American (AA) and white American (WA) women who seek treatment for ovarian cancer in the USA.

Background Among gynaecologic malignancies in the USA, epithelial ovarian cancer continues to be the leading cause of death, surpassing uterine and cervical cancer combined. An estimated 21 990 women were diagnosed with ovarian cancer in 2011 in the USA. Despite advances in surgical techniques and chemotherapy that have provided an increasing number of treatment options for women with this disease, mortality remains high, with 15 460 women dying from ovarian cancer in 2011. These outcomes reflect the fact that there is no effective screening tool for ovarian cancer. Thus, the majority of cases are diagnosed in advanced stages, and prognosis is usually poor. In addition, race has been postulated to be a prognostic factor of survival in women with ovarian cancer in a number of studies. Large epidemiological studies have demonstrated a lower incidence and death rate with epithelial ovarian cancer for AA compared with Caucasians. However, relative survival for AA appears to be significantly poorer. This research hypothesizes that this difference is not biologically determined, rather, it is the result of social inequalities. A literature review is required to assess the relationship between race and survival outcomes of ovarian cancer in AA and WA women in the USA.

Methods Literature review of English peer-reviewed studies regarding differences in survival outcomes for black and white ovarian cancer patients in the USA. Studies assessed by HRs, forest plots, Kaplan–Meier survival plots, 5-year survival rates and statistical significance.

Results Statistically significant results were demonstrated in two studies: Chan et al, 2008 (HR: 1.179, 1.095 to 1.270, 95% CI) Albain et al, 2009 (HR: 1.48, 1.03 to 2.11, 95% CI). 5-year survival rate (AA vs WA): Chan et al, 2008 (40.7% vs 44.1%), Albain et al, 2009 (17.8% vs 29.9%).

Conclusions Despite statistically significant evidence demonstrating that AA women experience worse survival outcomes in ovarian cancer than WA women, it would be premature to conclude that race is the only prognostic factor. Race is a social determinant that influences other variables that affect treatment and survival of ovarian cancer, such as education, occupation, socioeconomic status and access to healthcare. Therefore, future studies are required to further assess the complicated relationship between survival outcomes and race.