Introduction BRCA1/2 mutation carriers might be more sensitive to ionising radiation due to impaired DNA repair mechanisms.
Methods A retrospective European collaborative cohort study (GENE-RAD-RISK) of 1993 female BRCA1/2 mutation carriers was performed using self-reported exposure to diagnostic radiation. Risk of breast cancer was estimated using a weighted Cox proportional hazards model with cumulative radiation exposure from diagnostic procedures as a time-dependent variable lagged by 5 years.
Results are not presented in the abstract due to a publication embargo.
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