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Chronic disease
SP1-47 Associations between Persistent Organic Pollutants (POPS) in visceral and subcutaneous adipose tissue and insulin resistance
  1. Y M Lee1,
  2. S A Kim1,
  3. S G Kim2,
  4. I K Lee3,
  5. B Y Chun1,
  6. D H Lee1
  1. 1Department of Preventive Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea
  2. 2Department of Surgery, School of Medicine, Kyungpook National University, Daegu, Republic of Korea
  3. 3Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea

Abstract

Introduction Persistent Organic Pollutants (POPs) is recently linked to insulin resistance and type 2 diabetes. Although POPs are mostly bioaccumulated in adipose tissues, most studies have measured serum concentration of POPs because of difficulties of collecting adipose tissues. This study was performed 1) to compare patterns of concentrations of POPs between visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT), and 2) to investigate associations of insulin resistance with concentrations of POPs in VAT or SAT.

Methods We collected both VAT and SAT from 50 patients who underwent abdominal surgery and analysed 14 organochlorinated pesticides (OCPs) and 19 Polychlorinated biphenyls (PCBs). Insulin resistance was estimated using homeostasis model assessment method (HOMA-IR).

Results Concentrations of OCPs and PCBs among VAT and SAT were highly correlated, but absolute concentrations of PCBs in VAT were 3–4 times higher than those of SAT. As concentrations of p,p'-DDT, p,p'-DDD, cis-nonachlordane, trans-nonachlordane, PCB28, PCB105, and PCB118 in VAT or SAT increased, HOMA-IR significantly increased. The risk of elevated HOMA-IR (>50th percentile) was 5 to 10 times higher among subjects in the 3rd tertile of these POPs compared with those in the 1st tertile. Although here are some differences depending on individual POP, the positive associations between POPs and HOMA-IR were generally more obvious in VAT than SAT. Also, the extent of macrophage infiltration in VAT was positively associated with concentrations of POPs in VAT, not SAT.

Conclusion The current study strongly suggested that some POPs accumulated in VAT may be involved in the development of insulin resistance.

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