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P2-495 Predictive factors for non-repetition of the tuberculin test in patients with HIV/AIDS: a survival analysis
  1. L C R V Moura2,
  2. M D F P M Albuquerque1,
  3. R Ximenes2,3,
  4. H R Lacerda2,3,
  5. D M Filho2,3,
  6. R M S Silva1,
  7. C D P Freitas2,
  8. M R L Byington4,
  9. M T S Barbosa5
  1. 1Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz, Recife, Pernambuco, Brazil
  2. 2Departamento de Medicina Tropical, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil
  3. 3Universidade de Pernambuco, UPE, Recife, Pernambuco, Brazil
  4. 4Instituto Nacional do Cancer, Rio de Janeiro, Rio de Jeneiro, Brazil
  5. 5Departamento de Matemática e Estatística, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil

Abstract

Introduction Periodic repetition of the tuberculin skin (TST) test in individuals with HIV/AIDS with an initially non-reactive test should be carried out to identify those who should be treated for latent tuberculosis as recommended by the Brazilian Ministry of Health.

Methods A cohort of HIV positive patients who had initially tested non-reactive to the TST were followed up for the period between November 2007 and February 2010. The Kaplan–Meier method was used to estimate the probability of not repeating the TST and Cox's Regression analysis used to analyse the factors associated with the time until TST was repeated. Cox's multivariate analysis was stratified according to the hospital the patients were followed, as this variable did not respect the principle of proportionality of risk.

Results The probability of not repeating the TT by the end of the follow-up period was 42%. The variables that remained associated with repetition of the TT in the final Cox multivariate model were: aged 40 years or more, BMI between 18.0 and 24.9, being female, and years of schooling.

Conclusion The analysis identified groups of individuals who should be the target of interventions aiming to ensure the TT is repeated following an initial non-reactive test in individuals infected with HIV.

  • Tuberculin test
  • PPD
  • latent tuberculosis
  • preventive therapy
  • HIV/Tuberculosis co-infection
  • health service evaluation

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