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O3-3.2 Low vitamin D status and risk of type 2 diabetes: a prospective cohort study
  1. L Husemoen1,
  2. B Thuesen1,
  3. C Glümer1,
  4. M Fenger2,
  5. T Jørgensen1,
  6. L Ovesen3,
  7. J Svensson4,
  8. K Borch-Johnsen5,
  9. A Linneberg1
  1. 1Research Centre for Prevention and Health, Glostrup, Denmark
  2. 2Department of Clinical Biochemistry, Hvidovre Hospital, Hvidovre, Denmark
  3. 3Deptartment of Medical Gastroenterology, Slagelse Hospital, Slagelse, Denmark
  4. 4Department of Pediatrics, Glostrup Hospital, Glostrup, Denmark
  5. 5Institute of Public Health, University of Sourthern Denmark, Odense, Denmark


Introduction Low vitamin D status has been associated with higher risk of type 2 diabetes in cross-sectional studies. The evidence from prospective studies is limited. The aim was to examine the association between vitamin D status and risk of type 2 diabetes and markers of glucose homeostasis in a prospective cohort study.

Methods The study is part of the INTER99 study, based on a random sample of the general population of Copenhagen, Denmark. The current study included 6045 men and women aged 30–65 years at baseline (1999–2000). 4296 participated in the follow-up examination 5 years later (2004–2006). Data were collected with self-administered questionnaires, a physical examination, a 2 h oral glucose tolerance test, and various blood tests including measurement of serum 25-hydroxyvitamin D (25 (OH)D). Data were examined in multivariate logistic and linear regression models.

Results Low vitamin D status (25 (OH)D <25 nmol/l) was significantly associated with increased prevalence (OR 95% CI 1.62 (1.13 to 2.32)) and incidence (OR 95% CI 2.04 (1.38 to 4.17)) of diabetes compared to normal status (25 (OH)D ≥50 nmol/l). Moreover, low vitamin D status was significantly associated with markers of glucose homeostasis (glucose, insulin, c-peptide, Haemoglobin A1c, and insulin resistance (assessed by the HOMA model and the BIGTT test)) as well as unfavourable changes in these during follow-up.

Conclusion Low vitamin D status was associated with increased risk of type 2 diabetes and markers of glucose homeostasis in a Northern European general population sample.

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