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Global problems
P2-390 Cardiovascular and diabetes risk in persons with prediabetes
  1. T Dzebisashvili
  1. Moscow Regional Research Clinical Institute, Moscow, Russia

Abstract

Aim To assess RR of type 2 diabetes (T2DM), overall and acute cardiovascular mortality and cardiovascular events in persons with impaired fasting glucose (IFG) and impaired glucose tolerance (IGT).

Materials and Methods According to population based study among 2508 adults, the 3-year risk of T2DM, overall and acute cardiovascular mortality and cardiovascular events (fatal and nonfatal myocardial infarction and stroke, coronary heart disease) was estimated in people with glucose metabolism abnormalities (GMA): IFG, IGT, IFG+IGT diagnosed in 2006 in comparison with normal glucose tolerance. RR and regression coefficient (B) was calculated using Cox-regression analysis. RR of T2DM, cardiovascular events was adjusted for age, sex, BMI, systolic blood pressure (SBP), smoking.

Results Highest adjusted RR of T2DM were in IFG+IGT (11.2 [3.93–31.65], p<0.01). Lowest RR of T2DM were in isolated IGT (3.92 [1.11–13.90], p=0.034). Adjusted RR of cardiovascular mortality was significantly 3.2-fold higher in IFG. IGT and newly diagnosed T2D had significantly 3.6-fold and 2.3-fold greater risk of overall mortality. RR of cardiovascular events was significantly increased 2.2-fold in IFG and 2.7-fold in T2D. There was not linear association between blood glucose levels and cardiovascular mortality risk (p=0.095) in contrast to the continuous linear relationship observed between blood glucose levels and coronary heart disease risk B=0.273 (p=0.001).

Conclusion 3 year risk of T2DM is not equal at different early GMA: highest one –in IFG+IGT, lowest – in isolated IGT. IFG increased 3-year risk of acute cardiovascular mortality. There was not linear association between blood glucose levels and cardiovascular mortality risk.

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