Article Text


Chronic disease
P2-319 Cord blood vitamin D levels are associated with early life atopic dermatitis
  1. G Wegienka1,
  2. S Havstad1,
  3. D Ownby2,
  4. E Zoratti1,
  5. C C Johnson1
  1. 1Henry Ford Hospital, Detroit, Michigan, USA
  2. 2Medical College of Georgia, Augusta, Augusta, USA


Introduction Vitamin D deficiency (25-hydroxyvitamin D [25(OH)D]<50 nmol/l) is epidemic in many regions. Recent evidence indicates a possible association between low vitamin D levels and early life allergic disease.

Methods We examined the relationship between cord blood 25(OH)D and atopic dermatitis (AD) in the first 2 years of life in our birth cohort of children born to a predominantly African American population (67.7%) of mothers. Pregnant women living in Detroit, Michigan, USA, and its suburbs were enrolled and their children underwent a standardised physician exam at age 2 years. AD was evaluated by trained physicians.

Results Among children of African American mothers, 87/329 (26.4%) ever had AD while 19/157 (12%) children of White mothers ever had AD. Overall, cord blood 25(OH)D levels were lower in children who ever had AD (geometric means=GM 30.6 vs 35.6 nmol/l, Wilcoxon Rank Sum=WRS p=0.02); but the difference was driven by White children (GM 39.7 vs 50.9 nmol/l, WRS p=0.036) and not African American children (GM 29.4 vs 29.6 nmol/l, WRS p=0.81). The association was also modified by season of birth. Lower 25(OH)D levels were found in children with AD born during summer (GM 35.8 vs 45.2, WRS p=0.02), fall (GM 28.1 vs 33.8, WRS p=0.036) and winter (GM 30.0 vs 33.7, WRS p=0.15), but not spring (GM 30.8 vs 31.4, WRS p=0.90).

Conclusion Cord blood vitamin D is associated with AD at 2 years of age in White but not African American children. The association is also influenced by season of birth.

Statistics from

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.