Objective To evaluate the impact of weight change on cardiovascular risk factors in Japanese male workers stratified into younger (25–44 years) and older (45–64 years) age groups.
Methods Using the 2008 and 2009 health examination data of the Tokyo Health Service Association, eligible 49 587 male workers aged 25–64 years without medical treatment were examined their 1 year changes in body weight. Among those classified as normal weight or overweight, whose blood sample had been taken in the fasting state in both 2008 and 2009 (n=24 136), multiple logistic regression analyses were performed to calculate adjusted ORs of having any cardiovascular risk factors (hypertension, hyperglycemia, and dyslipidemia) at 1-year follow-up.
Results Overweight (BMI≥25) was more prevalent in the older group (27.5% vs 24.6%), whereas mean weight change (adjusted for baseline values) was significantly greater in the younger group (+0.26 kg vs −0.06 kg). The ORs of having cardiovascular risk factors after 1 year increased linearly with weight gain, and decreased linearly with weight loss. In terms of population attributable risk percentage, weight gain showed a greater contribution to the development and maintenance of cardiovascular risk factors in the younger group (20.1%) than in the older group (4.5%).
Conclusion Weight change was accompanied by significant changes in cardiovascular risk factors in Japanese male workers. The age-stratified estimates of population attributable risks suggest that weight control may have a greater impact on cardiovascular health in younger than in older male workers.
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