Introduction In the UK, approximately 11% of newly registered PrCa cases are under the age of 60 years. The unequal incidence across different countries suggests that modifiable factors, such as dietary intake of omega 3 polyunsaturated fatty acids (PUFAs) may be important.
Methods Data were analysed on 805 cases and 1283 controls of age <60 years. A food frequency questionnaire assessing typical diet 5 years previous to either diagnosis in the cases or returning questionnaire in controls was used to assess dietary PUFAs. Nutrient intake of specific PUFA derivatives was then calculated via a nutritional database. Unconditional logistic regression was used to calculate ORs and 95% CIs for the effect of omega 3 and its derivatives docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), α-linolenic acid (αLNA) and supplementation of total omega 3, DHA and EPA on PrCa risk after adjusting for confounders. Linear trend was also assessed.
Results For the highest compared with the lowest quartile of intake, total omega 3 dietary intake (OR=0.68, 95% CI 0.40 to 1.15, p=0.14), DHA (OR=0.71, 95% CI 0.48 to 1.05, p=0.09) and EPA (OR=0.72, 95% CI 0.46 to 1.14, p=0.16), all showed non-significant trends with decreased PrCa risk. However, increased supplement dosage of DHA and EPA both showed significant, protective dose-response relationships (p for trends=0.04).
Conclusion This study of early onset prostate cancer has shown protective trends for supplement intakes of DHA and EPA which if confirmed in other studies could have implications for prevention.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.