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Chronic disease
P2-250 Omega 3 polyunsaturated fatty acids (PUFAs) and risk of early onset prostate cancer
  1. A Atta Ur Rahman1,
  2. A Lophatananon2,
  3. J Lobaz3,
  4. F Robinson4,
  5. S S Brown2,
  6. T Parker4,
  7. D Easton5,
  8. Z Kote-Jarai6,
  9. R Pocock7,
  10. D Dearnaley6,
  11. M Guy6,
  12. R A Wilkinson6,
  13. A L Hall9,
  14. E Sawyer6,
  15. E Page6,
  16. J-F Liu8,
  17. R A Eeles6,9,
  18. K R Muir2
  1. 1Community Medicine and Public Health Sciences, Liaquat University of Medical and Health Sciences, Jamshoro, Sindh, Pakistan
  2. 2Health Sciences Research Institute, Warwick Medical School, Warwick University, Coventry, UK
  3. 3Division of Epidemiology and Public Health, University of Nottingham, Nottingham, UK
  4. 4School of Biomedical sciences, University of Nottingham, Nottingham, UK
  5. 5CR-UK Genetic Epidemiology Unit, Strangeways Research Laboratories, Worts Causeway, Cambridge, UK
  6. 6Institute of Cancer Research, Sutton, Surrey, UK
  7. 7Royal Devon and Exeter NHS Foundation Trust, Barrack Road, Exeter, UK
  8. 8Children's Brain Tumour Research Centre, Division of Human Development, University of Nottingham, Queens Medical Centre, Nottingham, UK
  9. 9The Royal Marsden NHS Foundation Trust, Downs Road, Sutton, UK

Abstract

Introduction In the UK, approximately 11% of newly registered PrCa cases are under the age of 60 years. The unequal incidence across different countries suggests that modifiable factors, such as dietary intake of omega 3 polyunsaturated fatty acids (PUFAs) may be important.

Methods Data were analysed on 805 cases and 1283 controls of age <60 years. A food frequency questionnaire assessing typical diet 5 years previous to either diagnosis in the cases or returning questionnaire in controls was used to assess dietary PUFAs. Nutrient intake of specific PUFA derivatives was then calculated via a nutritional database. Unconditional logistic regression was used to calculate ORs and 95% CIs for the effect of omega 3 and its derivatives docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), α-linolenic acid (αLNA) and supplementation of total omega 3, DHA and EPA on PrCa risk after adjusting for confounders. Linear trend was also assessed.

Results For the highest compared with the lowest quartile of intake, total omega 3 dietary intake (OR=0.68, 95% CI 0.40 to 1.15, p=0.14), DHA (OR=0.71, 95% CI 0.48 to 1.05, p=0.09) and EPA (OR=0.72, 95% CI 0.46 to 1.14, p=0.16), all showed non-significant trends with decreased PrCa risk. However, increased supplement dosage of DHA and EPA both showed significant, protective dose-response relationships (p for trends=0.04).

Conclusion This study of early onset prostate cancer has shown protective trends for supplement intakes of DHA and EPA which if confirmed in other studies could have implications for prevention.

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