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Chronic disease
P2-188 Prospective study of albuminuria on cardiovascular disease mortality and morbidity in the general population
  1. P Metcalf,
  2. R Scragg
  1. University of Auckland, Auckland, New Zealand

Abstract

Introduction Albuminuria predicts cardiovascular disease (CVD) in people with diabetes mellitus. However, few studies have been carried out in the general population.

Methods A total of 5260 participants aged ≥40 years from worksites in New Zealand were interviewed between 1988 and 1990. Participants were followed for up to 19 years. First CVD events were defined using ICD-9 and ICD-10 coding. Early morning urinary albumin levels of 30–300 mg/l were classified as microalbuminuric (n=249) and those above 300 mg/l as proteinuric (n=23). HRs were calculated after adjusting for age, gender and ethnicity in the total population and after excluding participants with new or previously diagnosed diabetes (n=5010).

Results Microalbuminuria was associated with increased hazards rates for all CVD events, all-cause mortality, CVD morbidity and mortality in the total population and after excluding participants with diabetes (Abstract P2-188 table 1). Similarly, proteinuria was only associated with increased HRs for all CVD events and mortality (Abstract P2-188 table 1). HRs remained significant after further adjusting for body mass index, lipids and hypertension.

Abstract P2-188 Table 1

HRs (95% CI)

Conclusion Microalbuminuria was associated with all-cause mortality and CVD morbidity and mortality in both the general population and in non-diabetic participants and may represent generalised vascular damage.

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