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Chronic disease
P2-178 The associations of dietary folate, vitamin B6 and B12 intakes with risk of sudden cardiac death: the Circulatory Risk in Communities Study (CIRCS)
  1. M Maruyama1,2,
  2. T Ohira1,2,
  3. H Imano1,2,
  4. A Kitamura2,
  5. M Kiyama2,
  6. T Okada2,
  7. K Maeda2,
  8. K Yamagishi3,
  9. H Noda2,4,
  10. Y Ishikawa2,
  11. T Shimamoto2,
  12. H Iso1
  1. 1Department of Social and Environmental Medicine, Osaka University, Suita, Japan
  2. 2Osaka Medical Center for Health Science and Promotion, Osaka, Japan
  3. 3Department of Public Health Medicine, University of Tsukuba, Tsukuba, Japan
  4. 4Department of Health Care Economics and Industrial Policy, Suita, Japan

Abstract

Introduction To examine whether dietary folate, vitamin B6 and B12 intakes are associated with the risk of sudden cardiac death (SCD) among Japanese men and women.

Method We conducted a nested case-control study. For each case of SCD entered between 1973 and 2001 in the CIRCS, two controls were randomly selected for each case and matched for age (±3 years), sex and community from among participants without history of SCD. The 77 cases and 154 controls aged 30–84 years were enrolled. Dietary folate, vitamin B6 and B12 intakes were assessed by 1 day 24 h dietary recall. We calculated conditional OR and 95% CI of each nutrients for risk of SCD adjusted for potential confounding factors.

Result Higher intake of folate was associated with lower risk of SCD. The multivariable adjusted OR (95% CI) of highest quartile was 0.32 (95% CI 0.12 to 0.82), p for trend=0.06 compared with lowest quartile. However, vitamin B6 and B12 intakes were not associated with risk of SCD. The multivariable adjusted OR (95% CI) of highest quartile of vitamin B6 and B12 intakes were 1.25 (95% CI 0.49 to 3.21), p for trend=0.64 and 0.83 (95% CI 0.34 to 1.98), p for trend=0.86 compared with lowest quartiles, respectively.

Conclusion Our findings suggest that higher dietary folate intake is associated with lower risk of SCD among Japanese men and women.

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