Introduction To examine whether dietary folate, vitamin B6 and B12 intakes are associated with the risk of sudden cardiac death (SCD) among Japanese men and women.
Method We conducted a nested case-control study. For each case of SCD entered between 1973 and 2001 in the CIRCS, two controls were randomly selected for each case and matched for age (±3 years), sex and community from among participants without history of SCD. The 77 cases and 154 controls aged 30–84 years were enrolled. Dietary folate, vitamin B6 and B12 intakes were assessed by 1 day 24 h dietary recall. We calculated conditional OR and 95% CI of each nutrients for risk of SCD adjusted for potential confounding factors.
Result Higher intake of folate was associated with lower risk of SCD. The multivariable adjusted OR (95% CI) of highest quartile was 0.32 (95% CI 0.12 to 0.82), p for trend=0.06 compared with lowest quartile. However, vitamin B6 and B12 intakes were not associated with risk of SCD. The multivariable adjusted OR (95% CI) of highest quartile of vitamin B6 and B12 intakes were 1.25 (95% CI 0.49 to 3.21), p for trend=0.64 and 0.83 (95% CI 0.34 to 1.98), p for trend=0.86 compared with lowest quartiles, respectively.
Conclusion Our findings suggest that higher dietary folate intake is associated with lower risk of SCD among Japanese men and women.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.