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Chronic disease
P2-162 Bone accrual at the forearm during adolescence: is prevention likely to work?
  1. R Lucas1,2,
  2. M Severo1,2,
  3. E Ramos1,2,
  4. H Barros1,2
  1. 1Department of Hygiene and Epidemiology, University of Porto Medical School, Porto, Portugal
  2. 2Institute of Public Health of the University of Porto, Porto, Portugal

Abstract

Introduction Whether bone quality is essentially modifiable or tracks predictably up to adulthood is unclear. We aimed to identify a biological timing when interventions may have optimal impact on future bone properties.

Methods Participants were 709 girls from a cohort of adolescents born in 1990 and evaluated at 13 and 17 years-old. Evaluations consisted of structured questionnaires including gynaecologic age (GA) and physical evaluations comprising height, weight, body composition (bioelectric impedance) and bone mineral density (BMD) at the forearm (dual-energy x-ray absorptiometry). Our outcome was BMD variation during follow-up. We used linear regression to estimate its associations with baseline BMD and anthropometry, in four GA classes at baseline: ≤−1, 0, 1 and ≥2 years relative to menarche.

Results Mean (95% CI) annual BMD variation from 13 to 17 years-old was highest in the earliest GA group (0.030 (0.028; 0.032) g/cm2-year) and lowest in the oldest GA (0.018 (0.016; 0.019)). Pearson's correlation between baseline BMD and its increase varied from −0.12 in the youngest to −0.45 in the oldest GA. After adjustment (baseline BMD, weight, fat mass and height) and standardisation, BMD variation in the lowest GA was associated with baseline BMD (−2.70 (−5.29; −0.108) per SD), but essentially with baseline weight (11.4 (0.523; 22.2)) and fat mass (−10.0 (−19.2; −0.912)). In the highest GA, BMD variation was strongly determined by baseline BMD (−5.44 (−7.20; −3.69)) but not by anthropometric variables.

Conclusion Bone quality tracking should be measured relative to GA. Bone accrual seems prone to modification, especially in earlier gynaecologic ages.

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