Objective Although weight loss in patients with type 2 diabetes is very important, the data on the effect of long-term weight change on blood pressure (BP), lipids and glycaemic control among patients with type 2 diabetes receiving routine care are limited. The aim of this study was to assess the long-term impact of weight change on BP, plasma lipids and glycaemic control among patients with type 2 diabetes receiving routine care.
Methods During the mean (SD) follow-up period of 9.2 (3.4) (range 2–15) years, 7712 patients with type 2 diabetes have been examined to determine changes in weight, BP, plasma lipids and glycaemic control using a linear mixed effects model for repeated measures. The mean (SD) age of participants was 51.3 (10.5) years with a mean (SD) duration of diabetes of 6.3 (6.3) years at initial registration.
Results The change in fasting plasma glucose and glycosylated haemoglobin (HbA1c) from baseline to last follow-up examination was significantly more favourable in those who gain weight during follow-up than those who lost weight or stable weight. Systolic and diastolic BP and lipids also raised significantly more in the group with weight gain.
Conclusions Although this population of Iranian type 2 diabetes had negligible weight change over mean 9.2 years. Weight gain in patients with type 2 diabetes was associated with increase in BP and plasma lipids, but improvement in glycaemic control.
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