Aims The aim of this study was to estimate the incidence of type 2 diabetes using newly proposed haemoglobin A1C (HbA1c) and current oral glucose tolerance test (OGTT) definition in an Iranian non-diabetic population.
Methods A total of 923 non-diabetic first-degree relatives of patients with type 2 diabetes 20–70 years old in 2003–2005 were followed through 2009 for the occurrence of type 2 diabetes. At baseline and through follow-ups, participants underwent a standard 75 g 2-h OGTT and HbA1c measurements. Prediction of progression to type 2 diabetes by OGTT-defined or HbA1c-defined was assessed with area under the receiver-operating characteristic curves based upon measurement of fasting plasma glucose, 2-h post-load glucose values and HbA1c.
Results The prevalence of type 2 diabetes was 9.2% (95% CI 8.2 to 10.2) by OGTT-defined diabetes and 7.9% (95% CI 6.9 to 9.0) by HbA1c ≥6.5. The incidence of type 2 diabetes was 2.0% (95% CI 1.6 to 2.4) (1.8% men and 2.1% women) per year by the current OGTT definition, whereas the incidence rates were 1.7% (95% CI 1.3 to 2.0) (1.6% men and 1.7% women) per year by HbA1c ≥6.5%. Of those diagnosed with type 2 diabetes by OGTT, 69.6% had HbA1c<6.5% and therefore would not have been classified as having type 2 diabetes.
Conclusions The incidence and prevalence of diabetes using newly proposed HbA1c threshold in this first-degree relatives of patients with type 2 diabetes was slightly lower than using current OGTT definition.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.