Article Text

PDF

Epidemiology and policy
P1-348 Leisure-time physical activity and breast cancer risk defined by oestrogen and progesterone receptor status: the Japan public health center-based prospective study
  1. R Suzuki1,
  2. M Iwasaki1,
  3. S Yamamoto2,
  4. M Inoue1,
  5. S Sasazuki1,
  6. N Sawada1,
  7. T Yamaji1,
  8. T Shimazu1,
  9. S Tsugane1
  1. 1Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tsukiji, Chuo-ku, Tokyo, Japan
  2. 2Cancer Information Services and Surveillance Division, Center for Cancer Control and Information Services, National Cancer Center, Tsukiji, Chuo-ku, Tokyo, Japan

Abstract

Objective To investigate the association between leisure-time physical activity (LPA) and breast cancer risk in consideration of tumour oestrogen/progesterone-receptor (ER/PR) status.

Methods We conducted a population-based prospective cohort study among 53 578 women in the Japan Public Health Center-based Prospective Study. LPA was assessed by self-reported questionnaires. A Cox proportional hazards regression model was used to derive RRs and 95% CIs.

Results From 1990 to 1993 to the end of 2007, 652 cases were identified. The absolute rate of breast cancer was 84 per 100 000 person-years among the sedentary groups (?3 days/month). We observed a statistically significant inverse association between LPA and breast cancer risk (RR ?3 days/week vs ?3 days/month =0.73; 95% CI 0.54 to 1.00; p trend 0.037), particularly in ER+PR+(RR 0.43; 95% CI 0.19 to 1.00; ptrend 0.022) and this inverse trend was apparent among postmenopausal women (RR 0.25; 95% CI 0.06 to 1.06; p trend 0.041). An inverse trend was also observed between daily total physical activity and postmenopausal ER+PR+ risk (p=0.046). Among BMI ?25 kg/m2 group, LPA was associated with decreased risk (RR ?1 days/week vs ?3 days/month =0.65; 95% CI 0.43 to 0.97; p trend 0.033).

Conclusion Active participation in LPA may contribute to a decrease in breast cancer risk, particularly for postmenopausal ER+PR+ tumours.

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.