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Epidemiology and policy
P1-344 Coronary artery lesions of incomplete kawasaki disease: the Nationwide survey of 2007–2008 in Japan
  1. D Sudo1,
  2. Y Monobe1,
  3. M Yashiro1,
  4. M Mieno1,
  5. R Uehara1,
  6. K Tsuchiya2,
  7. T Sonobe2,
  8. Y Nakamura1
  1. 1Jichi Medical University, Shimotsuke, Japan
  2. 2Japanese Red Cross Medical Center, Shibuya-ku, Japan

Abstract

Objectives To observe the recent epidemiologic features of incomplete Kawasaki disease (KD) patients reported to the Japanese nationwide survey, and to compare risk factors for developing coronary artery lesions (CALs) between incomplete KD and complete KD.

Methods In the 2007–2008 nationwide survey, 23 337 KD patients were reported and then classified by their number of principal symptoms for analyses. In this study, complete KD was defined as having five or more of the six principal symptoms; incomplete KD as having four or fewer regardless of the presence or absence of CALs.

Results Compared with complete KD patients, younger ages at first hospital visit, a higher incidence rate of CALs, less frequency of both initial and additional intravenous immunoglobulin (IVIG) administration, later IVIG administration, less total dose of IVIG administration, and less frequency of steroid therapy were observed among those with incomplete KD. Also particularly in patients having CALs, the same delayed and insufficient IVIG therapy was observed in incomplete KD. Multivariate analysis showed that the risk factors for CALs observed in incomplete KD were almost the same as those observed in complete KD, except for receiving initial IVIG therapy. The initial IVIG administration was risk of developing CALs in incomplete KD, but not risk rather protective in complete KD.

Conclusions The results imply the existence of a common pathological basis in generating CALs regardless of presentation types of KD. Therefore, more timely diagnosis and treatment to incomplete KD patients could lead to the further prevention of cardiac lesions caused by KD.

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