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Epidemiology and policy
P1-332 First insight into genetic diversity of Mycobacterium tuberculosis strains in Salvador, Brazil
  1. A Silva1,
  2. L Ferrazoli3,
  3. J Reis1,
  4. S Pereira2,
  5. E Mota2,
  6. M Reis1
  1. 1Centro de pesquisa gonçalo muniz, Fundação oswaldo cruz-bahia, Salvador, Bahia, Brazil
  2. 2Universidade federal da Bahia, Instituto de saúde coletiva, Salvador, Bahia, Brazil
  3. 3Instituto adolfo lutz, IAL, São Paulo, São Paulo, Brazil

Abstract

This study constitutes a first attempt to describe the genetic population structure of M tuberculosis circulating in Salvador. A total of 56 confirmed cases of pulmonary tuberculosis, identified between March and June, 2008 were analysed using IS6110-restriction fragment length polymorphism (RFLP). The study population was characterised by male (71.4%) and over 30 years of age (68.7%). Forty-one isolates were found in a single pattern (73.21%), while 15 (26.78%) were found in group patterns, forming six clusters. The higher rate of diversity observed is much more suggestive of endogenous reactivation than recent transmission.

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