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Epidemiology and policy
P1-307 Higher cancer detection risk in women with a false positive result in breast cancer screening in Spain
  1. J Blanch1,
  2. A Romero1,
  3. M Sala1,
  4. R Román1,
  5. D Salas2,
  6. R Zubizarreta3,
  7. M Ederra4,
  8. M Baré5,
  9. J Galceran6,
  10. I González-Román7,
  11. C Natal8,
  12. M de la Vega9,
  13. A Baroja10,
  14. F Macià1,
  15. X Castells1
  1. 1Department of Epidemiology and Evaluation, IMIM-Parc de Salut Mar, CIBERESP, Barcelona, Spain
  2. 2General Directorate Public Health & Centre for Public Health Research, Valencia, Spain
  3. 3Galician breast cancer screening programme. Public health & Planning Directorate. Health Office, Santiago de Compostela, Spain
  4. 4Navarra Breast Cancer Screening Programme. Public Health Institute, CIBERESP, Pamplona, Spain
  5. 5OTC-Epidemiology, Sabadell, Spain
  6. 6PDPCM, League Foundation and Cancer Prevention Research, IISPV, Reus, Spain
  7. 7Castilla-Leon Breast Cancer Screening Programme, D G Salud Pública ID e I, SACYL, Valladolid, Spain
  8. 8Unit of Analysis and Programs. Health Service of Asturias, Oviedo, Spain
  9. 9General Directorate of Health Care Programmes. Canary Islands Health Service, Santa Cruz de Tenerife, Spain
  10. 10La Rioja Breast Cancer Screening Programme, Fundacion Rioja Salud, Logroño, Spain

Abstract

Introduction Breast screening reduces mortality from breast cancer through early detection. Despite its benefits, breast cancer screening presents some adverse effects, as false positive (FP) results. Our aim was to estimate the risk of cancer detection associated to have experienced a previous FP mammography.

Methods The Cumulative False Positive Risk study includes eight population-based screening programs in Spain, between 1990 and 2006, that invites women aged between 45/50 and 69 years, with no previous breast cancer. We included women participating in at least two screenings rounds. A positive mammogram reading was considered a FP result if, after further assessments, breast cancer was not diagnosed. Cancer detection risk was estimated through OR with a multivariate discrete-time-hazard model with a random intercept. The model included adjusting variables related to screening programs (radiologic unit, reading method and number of projections) and woman (age, hormone replacement therapy use, menopausal status, previous invasive procedures and familial history of breast cancer).

Results Women who had experienced at least one previous FP result had a higher cancer detection rate than those without a FP (4.72 per 1000 mammograms vs 2.56 per 1000 mammograms). The adjusted OR of cancer detection was higher in women with a FP in any previous screening (OR=1.88 95% CI 1.76 to 2.00).

Conclusion Women with a previous FP result had a higher risk of cancer detection. This result may suggest that factors related to FP could provide useful information to redesign different early detection strategies for specific subgroups of women.

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