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Epidemiology and policy
P1-244 The cognitive function and ageing study (CFAS) II: neurobiology, cognitive impairment and dementia study protocol study protocol
  1. T Minett on behalf of CFAS II team and investigators
  1. Cambridge University, Cambridge, Cambridgeshire, UK


Background The increasing number of people with cognitive decline and dementia are consequences of the population ageing. The Cognitive Function and Ageing Study (CFAS), initiated 20 years ago, has informed understanding of the prevalence of cognitive decline and dementia, the costs they generate, as well as implications for policy regarding projections for the future. CFAS is being replicated, as far as possible, in the current generation of those aged 65 years and over. Information in health and cognitive status across the two cohorts will demonstrate the impact of generational changes on the prevalence of age related diseases and their influence on life expectancy.

Methods A target sample of 12 500 individuals aged 65+ is being recruited in five centres (Cambridgeshire, Newcastle upon Tyne, Nottingham, Gwynedd and Neath Port Talbot). Eligible individuals were randomly selected from primary care trusts to health board registries. Assessment consists on multi-dimensional aspects of health, collection of saliva samples, and permission for review of general practice medical records. Those, who consent, will be flagged with the National Health Service central register to provide details of the date and cause of death.

Results Collection of data are still ongoing and we will present what was collected up until December 2011.

Conclusions CFAS II, in combination with its parent study will address key questions about health, diseases, associated disability, policy projections across generations of older people, who will reach the age of greatest frailty in the 2020s when the peak in numbers of 85 and over is expected.

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