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J Epidemiol Community Health 2009;63:4 doi:10.1136/jech.2009.096701d
  • Wednesday 9 September, Parallel session A
  • Life course CVD

Lifecourse predictors of adult fibrinogen concentrations: the Newcastle Thousand Families Birth Cohort

  1. M. S. Pearce1,
  2. A. Ahmed2,
  3. P. W. G. Tennant1,
  4. L. Parker3,
  5. N. C. Unwin1
  1. 1
    Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK
  2. 2
    London School of Hygiene and Tropical Medicine, London, UK
  3. 3
    Departments of Medicine and Paediatrics, Dalhousie University, Halifax, NS, Canada

      Objectives

      To investigate the relative influences of early life and later determinants of plasma fibrinogen concentrations at age 49–51 years.

      Design

      Follow-up study of the Newcastle Thousand Families birth cohort established in 1947.

      Participants

      173 men and 221 women who attended a clinical examination between October 1996 and December 1998 and also gave blood samples.

      Main Outcome Measure

      Concentration of plasma fibrinogen. This was analysed, using linear regression, in relation to a range of variables at different stages of life, …

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