Article Text

PDF
Endocrine disruption
  1. Nicolas Olea,
  2. Marieta Fernández
  1. Hospital Clínico, University of Granada, Granada, Spain
  1. Correspondence to:
 Professor N Olea
 Lab Medical Investigations, Hospital Clinico, University of Granada, 18071 Granada, Spain; nolea{at}ugr.es

Statistics from Altmetric.com

Understanding the risks that endocrine disrupters pose to human health is limited by inadequate knowledge of the effects of chronic, low-level and early-life exposures in adult life

Environmental pollutants may exert adverse physiological effects by disrupting normal endocrine function. Chemicals with this capacity, designated endocrine disrupters (EDs), are defined as exogenous substances that alter the function(s) of the endocrine system, thereby producing adverse health effects in an intact organism or its progeny or (sub)populations.

The endocrine disruption hypothesis was originally developed for chemicals that affected the oestrogen-signalling pathway. Thus, most research on endocrine disruption to date has been focused on oestrogenic effects. However, it is now becoming generally accepted that several types of compounds can interact with components of cell-regulatory systems, including steroid and thyroid hormone-receptor families. Endocrine disruption via nuclear receptors in cells of many organs of the body could affect the development and functioning of brain, cardiovascular, skeletal and urogenital systems.

Considerable progress has been made in the identification and quantification of a wide array of chemicals with endocrine disrupting properties. Research efforts have been centred on compounds that persist and bioaccumulate in organisms and their environment. Exposure to less persistent compounds has only recently been addressed. The existing safety assessment framework for chemicals is, unfortunately, poorly equipped to deal with EDs; tests and bioassays used take no account of the effects of simultaneous exposure to multiple chemicals, and may lead to a serious underestimation of the risks.

The vulnerability of a given species to EDs is determined by numerous factors: the intrinsic properties of the chemical; the magnitude, duration, frequency …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles

  • In this issue
    Carlos Alvarez-Dardet John R Ashton