Article Text

PDF
Oral presentation bias: a retrospective cohort study
  1. Evelyne Decullier1,
  2. François Chapuis2
  1. 1RECIF Clinical Research Unit, DIM des Hospices Civils de Lyon, Lyon Cedex 03, France
  2. 2EUREC European Research Ethics Committees Initiative, Claude Bernard University Lyon I, Lyon Cedex 03, France
  1. Correspondence to:
 F Chapuis
 RECIF Clinical Research Unit, DIM des Hospices Civils de Lyon, 162 Avenue Lacassagne, 69424 Lyon Cedex 03, France; francois.chapuis{at}chu-lyon.fr

Abstract

The aim of this paper was to assess oral presentation bias at a national level. This was a retrospective cohort study with initial characteristics of the approved protocols extracted from the committee’s archives, and follow-up characteristics obtained from a questionnaire mailed to the principal investigators. A representative sample of French research ethics committees (25/48), the only committees legally endorsed for ethical authorisation in biomedical research, were studied. All completed research protocols, which had been approved in 1994 by these committees, were included. Initial characteristics (design, study size, investigator) of completed studies and follow-up information (direction of results, rates of publication and rates of oral presentation) were collected. Complete information on results and their dissemination was available for 248 completed non-confidential protocols. Half of these (49%) were declared as orally presented. The observed ranking for strategies to disseminate results was the following: orally presented and published, published only, neither orally presented nor published and orally presented only. Confirmatory results were more often orally presented, with an adjusted OR of 6.4 (95% CI 2.69 to 15.22). Other associated variables are the following: national/international scope of the study, protocol writer’s university status, adverse events and interim analysis. There is a trend to submit or accept confirmatory results for oral presentations: meetings are a biased representation of research, and oral presentation bias could even be higher than publication bias.

Statistics from Altmetric.com

Footnotes

  • Funding: None of the funding sources were involved at any stage. The French Ministry of Health (Programme Hospitalier de Recherche Clinique 1998–065), Hospices Civils de Lyon, Claude Bernard University Lyon 1 and the French Ministry of Research and Higher Education for a PhD grant.

  • Competing interests: None.

  • Contributors: both authors had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.