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Breast feeding is related to C reactive protein concentration in adult women
  1. M J A Williams1,
  2. S M Williams2,
  3. R Poulton2
  1. 1Department of Medical and Surgical Sciences, University of Otago, Dunedin, New Zealand
  2. 2Department of Preventive and Social Medicine, University of Otago
  1. Correspondence to:
 Dr M Williams
 Department of Medical and Surgical Sciences, University of Otago, 201 Great King Street, Dunedin, New Zealand; michael.williams{at}otago.ac.nz

Abstract

Objective: To assess the influence of infant breast feeding on C reactive protein (CRP), a marker of low grade inflammation associated with cardiovascular mortality independent of serum cholesterol concentrations.

Design: Serum CRP, total cholesterol, anthropometric, and blood pressure measurements were performed along with assessment of infant breast feeding duration, birth weight, smoking status, adult socioeconomic status, number of health problems, and hormonal contraceptive use.

Setting: A New Zealand predominantly European descent community birth cohort.

Participants: 822 men and women aged 26 years.

Main results: There was a significant linear relation (p<0.001) between duration of breast feeding and adult CRP level in women. The geometric means (IQR) for CRP were 2.22 (1, 4) mg/l for women breast fed for six months or more and 3.95 (2, 8) mg/l for women not breast fed (ratio, 95% confidence interval (CI): 0.69 (0.55 to 0.87). The linear association between cholesterol and breast feeding was also significant (p = 0.01), the geometric mean (IQR) total cholesterol levels being 4.62 (4.10, 5.10) for those breast fed for six months or more and 5.04 (4.5, 5.80) for those not breast fed (ratio, 95% CI: 0.92 (0.87, 0.98). There was no relation between CRP or total cholesterol and duration of breast feeding in men.

Conclusions: The findings of lower CRP with an increased duration of breast feeding in women suggest early postnatal nutrition may influence long term cardiovascular risk.

  • breast feeding
  • C reactive protein
  • cholesterol
  • cardiovascular risk

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Footnotes

  • Funding: data collection was supported by grants from the National Heart Foundation of New Zealand, the University of Otago (Otago Research Grant), NIMH Grants MH45070 and MH49414, and the WT Grant Foundation. The funding sources had no involvement in the performance of the study or the writing of the manuscript.

  • Competing interests: none declared

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