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What next for low dose aspirin?
  1. Gareth Morgan
  1. Correspondence to:
 MrG Morgan
 Welsh Aspirin Group, 41 Ffordd Beck, Gowerton, Swansea SA4 3GE, UK; gareth.morgannphs.wales.nhs.uk

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Report from a conference on the public health potential of aspirin.

Aspirin (acetylsalicylic acid) is inexpensive, readily available, and widely used for the treatment of many common conditions. Undoubtedly, its most important use now is in vascular disease as a daily low dose (75–150 mg) leads to a substantial reduction in the risk of a vascular event or death.1,2 However, the drug is also associated with undesirable effects, most notably gastrointestinal irritation and bleeding,3 which limit its use.

Evidence is now accumulating that suggests that aspirin may confer a risk reduction against a range of other chronic diseases, in particular against cancer4 and possibly Alzheimer’s disease.5 Because of the established benefits in vascular disease and these possible further benefits, aspirin would seem to have far reaching public health potential. So should it be more widely promoted?

This question was raised at a conference “The public health potential of aspirin in Wales” organised by the Welsh Aspirin Group (WAG) on 6 May 2004. WAG chairman Professor Peter Elwood suggested that a public health strategy to promote the use of low dose aspirin should be carefully examined. As with other preventive programmes, such as influenza vaccination, the strategy he proposed would have two arms: the targeting of high risk patients and a general population approach based upon age alone.

The present policy in Wales for the reduction of vascular disease involves only the first of these. High risk patients, such as those with angina pectoris, hypertension, diabetes mellitus, or a prior vascular event, are identified and prophylactic measures targeted to them. The results of a very recent survey of patients in a representative sample of general practices across Wales were presented (Elwood, personal communication) showing that only about half the patients at high vascular risk are actually taking aspirin. Efforts to increase the use of aspirin in all patients at high risk, who are without a contraindication, are therefore needed as a matter of urgency. It was also recommended that the use of aspirin during the acute infarction phase, whether taken by the patients themselves (so called “immediate” aspirin), or given by paramedics (so called “early” aspirin) should be factored into the high risk arm of the public health strategy.6

It was argued, however, that the present policy for vascular prophylaxis only in high risk patients is deceptive as well as being inefficient. Evidence from the south Wales Caerphilly cohort study was used to show that less than half the vascular events that occur in a community occur among those subjects who have been defined as being at high vascular risk. Although the evidence was derived from a study on men, similar findings would reasonably be expected for women.

The conference therefore went on to consider the benefits of an extension of aspirin prophylaxis beyond patients identified as being at high risk. The incidence of vascular events increases with age and there will therefore be an average age within a community at which the overall benefit of taking low dose aspirin outweighs the risk of undesirable effects. Evidence from the Caerphilly cohort study was again briefly presented to illustrate that the men at about 50 years of age had an average vascular risk above that at which aspirin is usually recommended, namely a five year risk of 3%.7 Although no comparable data are available for women in Wales, the vascular benefits of aspirin have been recommended elsewhere for post-menopausal women7 and most of these will be aged 50 years and over.

In addition, the evidence on aspirin and both cancer and Alzheimer’s disease was considered. It was argued that although data from a number of sources suggest benefit from aspirin in these conditions, the evidence is at present inconclusive. The case for low dose aspirin must therefore be based on the vascular effects of the drug alone and any additional benefits would be a bonus.

The proposal was therefore made that vascular prophylaxis by low dose aspirin should be recommended on the basis of age alone. However, two important qualifications to the proposal were highlighted. Firstly, the evidence on the established and possible further benefits of low dose aspirin together with the evidence on the undesirable effects of the drug should be widely and repeatedly publicised. Aspirin is readily available and people should be encouraged to consider the possible benefits and risks for themselves and make their own informed decision about whether or not to take a low daily prophylactic dose. Secondly, aspirin must be recommended as a complement and not as an alternative to other measures that improve health. These include dietary and lifestyle changes as well as any drug regimen other than aspirin that may be advised for an individual patient.

A number of formal responses were made to the proposal of aspirin prophylaxis on the basis of age alone. The perspectives of the responses were from clinical medicine, public health, health policy, and health economics. They all expressed caution. For example, a clinician highlighted the paradox that exists between individuals and populations, in that some individuals who take aspirin may experience undesirable effects yet the population as a whole is likely to benefit. From a public health perspective it was observed that problems would follow if there were differential and inappropriate uptake of aspirin prophylaxis namely widening health inequalities and an increase in undesirable effects respectively. The health policy perspective drew attention to the present context in which such a strategy would be launched and recent controversies, such as MMR vaccination, that have affected public confidence in health services. From a health economics perspective the need for rigorous evaluation was emphasised, given that any prophylactic strategy will generate costs to individuals, to society, and to health services.

Considerable media interest plus feedback after the conference confirmed that the objective of increasing the profile of the public health potential of aspirin had been met. So what should happen next? While it is clear that efforts to increase the use of aspirin in all patients at high risk are urgently needed in Wales and other countries,8 the proposal of aspirin prophylaxis on the basis of age alone requires further consideration and an extensive process of public involvement. National public health agencies in the UK and other countries would seem to be the appropriate bodies to take a lead in this with possibly the World Health Organisation taking a coordinating role. In addition, there is a need for further research on aspirin and naturally occurring salicylates on the risk of non-vascular chronic diseases such as cancer.9 WAG is planning to convene a multidisciplinary exploratory workshop on salicylates in human health and disease.

Acknowledgments

The above is largely based on discussions at a conference “The public health potential of aspirin in Wales” organised by the Welsh Aspirin Group (WAG) on 6 May 2004. Gareth Morgan is secretary to the Welsh Aspirin Group and will provide a copy of the conference report on request.

Report from a conference on the public health potential of aspirin.

REFERENCES

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Footnotes

  • Funding: none.

  • Conflicts of interest: none declared.

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