Molecular biomarkers in studies on environmental cancer
- Finnish Institute of Occupational Health, Department of Industrial Hygiene and Toxicology, Topeliuksenkatu 41 aA, FIN-00250, Helsinki, Finland
- Correspondence to: Professor K Husgafvel-Pursiainen; Kirsti.Husgafvel-Pursiainen{at}ttl.fi
Molecular cancer epidemiology studies search for molecular effects associated with the aetiological factors involved in environmental cancer
Biomarkers used for identification of risk factors of cancer in exposed populations have traditionally been classified into markers of exposure, effect, and susceptibility.1,2 Along with the advances in our knowledge about molecular biology, human genome, chemical carcinogenesis, and disease mechanisms, a variety of biomarkers of a more molecular nature have been launched and are currently being used widely in this field of research.3–5 This concept is often called, with some criticism, molecular epidemiology or molecular cancer epidemiology.5–7 As illustrated by Porta and coauthors in their present paper,8 there has indeed been a dramatic increase in number of publications in this interdisciplinary field of research over the past decade or so.
In their article, Porta and his colleagues deal with certain aspects of molecular biomarker studies of cancer, in particular those relevant to studies investigating somatic mutations of genes controlling cell growth and differentiation such as DNA “fingerprints”—that is, indicators of the genotoxic nature of a chemical or exposure suspected of causal involvement. The authors themselves have performed several studies …
