Article Text

PDF

Milk, coronary disease and mortality
  1. PETER ELWOOD
  1. Department of Epidemiology and Community Health, University of Wales College of Medicine, University of Wales Hospital, Cardiff CF14 4XN, UK (pelwood{at}doctors.org.uk)

    Statistics from Altmetric.com

    Milk has long been under suspicion as an important factor in coronary heart disease because of its relatively high content of saturated fat and numerous people and expert groups have spoken and written in condemnation of milk and have recommended that only skimmed or semiskimmed milk is drunk—even by children.

    Many mechanisms have however been appealed to in attempts to explain the supposed harm of milk. Thus it has been argued that its high calcium content, together with an enhancement of the uptake of calcium from other foods by the lactose in milk, could increase arterial calcification, leading to myocardial ischaemia.1 On the other hand, animal proteins contribute to homocysteine and milk, unlike meat, contains little of the B vitamins needed for the metabolism of homocysteine.2 Milk is also low in copper, an essential element in many enzymes, and the lactose in milk interferes with the absorption of copper from other food sources.3 Chronic infections from milk borne bacteria, or algae, have been suggested as a contributory cause of atherosclerosis.4 Both phytoestrogens5 and xanthine oxidase6 are present in milk and both may enhance atheromatous plaque formation. The prevalence of lactose malabsorption within different communities matches both milk consumption and ischaemic heart disease mortality,7 and antibodies to heated milk proteins have been shown to be raised in patients with ischaemic heart disease.8 Finally, Popham et al 9 pointed out that there is a negative correlation between milk consumption and the intake of alcohol and subjects with a high milk intake may therefore deny themselves some of the cardiovascular protection from alcohol.

    On the other hand, mechanisms that are of possible benefit in relation to vascular disease have been suggested for milk. Protection from calcium has been suggested.10 The apparent paradox thought to be raised by the Masai, with their high milk intake but low coronary heart disease rates, has been explained by milk having an unknown hypocholesterol factor.11 On page 379 Nesset al make the further suggestion that increased growth in childhood consequent on a high milk intake, is associated with protection later against vascular disease.

    It is a relief to turn from these varied and conflicting hypotheses—however ingenious—to evidence from an observational study. Ness et al report results from a large prospective study in which information on milk consumption was obtained from over five and a half thousand men aged 35 to 64 years, and is now related to deaths during the following 25 years.

    The best evidence of course comes from randomised trials, and so far the relevance of milk consumption to cardiovascular death has not been tested in an RCT. A very small crossover trial in children showed that cow's milk had a greater cholesterolaemic effect than soy protein milk.12 Another RCT in 500 infants that tested the withholding of cow's milk and the provision of soya formula milk feed gave no evidence of any difference in asthma or other allergic condition.13 An RCT that is referred to by Nesset al is however of more direct relevance to cardiovascular disease in that it showed that the provision of a small milk supplement each school day enhanced the growth of children in large families of lower social class.14

    The conduct of an RCT of adequate size and duration to test the effect on coronary disease of the avoidance of cow's milk in adults would be a formidable undertaking. The level of conviction in the general community that fat from milk and other dairy products is a major cause of heart disease should however make the enlisting of subjects into an RCT relatively easy. On the other hand, the number of possible mechanisms in which milk may be involved would make it difficult to decide how complete milk avoidance would have to be, and for how long before an effect on cardiovascular incidence might be detected.

    In this situation, evidence from observational studies is probably the best we will ever have. The paper by Ness et al is therefore of particular interest. They find no evidence of an association between milk consumption and either cholesterol of triglyceride level. Nor do they find that milk consumption is associated with an increased risk of death, either from coronary heart disease or from all causes. Indeed the relative risk of death from any cause, after adjustment for confounding by a number of possible factors, is significantly reduced in the men with the highest intakes (more than one third of a pint (0.57 litres)) of milk per day, and the risk of death from coronary disease is also reduced (p=0.05).

    The authors are cautious and admit that there might still be residual confounding of the relations of interest. Milk drinking was certainly associated with a number of other factors indicative of better health and greater care, yet it would seem most unlikely that any harmful effect could have been missed.

    The overall conclusion of these authors: that the “notion” that regular consumption of milk is hazardous to health is not supported by their data, is consistent with studies already reported in the literature. They quote seven large prospective studies in none of which was there any significant excess in coronary disease incidence. Nor in several of the studies, was there any evidence of any increase in stroke risk. Indeed several other studies have suggested an inverse relation between fat intake and the incidence of stroke.

    Yet again, the superiority of epidemiology over conjecture about possible mechanisms is demonstrated.

    References

    View Abstract

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Linked Articles

    • Research report
      A R Ness G Davey Smith C Hart