Archie Cochrane will be remembered for many things, but perhaps more than anything for his enthusiastic promotion of the randomised controlled trial in clinical research, and for his call for periodic overviews of such trials. Yet Archie himself never conducted a randomised controlled trial!
In his paper “Sickness in Salonica: my first, worst, and most successful clinical trial”1 Archie described a trial of yeast in the …
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