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Impact of socioeconomic status on coronary mortality in people with symptoms, electrocardiographic abnormalities, both or neither: the original Whitehall study 25 year follow up

Abstract

OBJECTIVES To determine the impact of socioeconomic status (SES) on coronary heart disease (CHD) mortality in people with and without prevalent CHD at baseline.

DESIGN Cohort study with 25 year follow up; prevalent CHD was defined by Q, ST or T wave electrocardiographic (ECG) abnormalities or symptoms (defined by the Rose chest pain questionnaire and self reported doctor diagnosis) or both. SES was defined by four civil service employment grades.

SETTING London.

PARTICIPANTS 17 907 male civil servants aged 40–69 years.

MAIN OUTCOME MEASURES CHD mortality (n=2695 deaths).

RESULTS The lowest versus highest employment grade was associated with increased CHD mortality (age adjusted hazard ratio 1.56 (95% CI 1.2, 2.1)), prevalence of symptoms and, among symptomatic participants only, the prevalence of Q, ST or T abnormalities. Thirty one per cent of CHD deaths occurred in participants with prevalent CHD at baseline. Among participants without Q, ST or T abnormality employment grade was associated with CHD mortality; the hazard ratios (lowestv highest grade) adjusted for age, systolic and diastolic blood pressure were 1.72 (95% CI 1.4, 2.1) for asymptomatic and 1.52 (95% CI 1.1, 2.1) for symptomatic participants; among participants with Q, ST or T abnormality the corresponding hazard ratios were 1.46 (95% CI 0.7, 2.9) and 1.14 (95% CI 0.6, 2.0) respectively.

CONCLUSIONS SES was inversely associated with CHD mortality in civil servants with and without prevalent CHD at baseline. Further distinguishing the relative contribution of SES to the initiation and progression of CHD requires repeated measures studies of pre-clinical and clinical measures of CHD.

  • socioeconomic status
  • coronary mortality

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It is widely observed that socioeconomic status (SES) is inversely related to coronary heart disease (CHD) mortality1 and furthermore that these differences may be widening.2 SES may affect both the risk of developing CHD (aetiology) and survival among CHD cases (prognosis). However, most studies have concentrated on aetiology, with a few studies investigating prognosis3 4 and even fewer the relative impact of SES on aetiology and prognosis.5 Examining case fatality in prevalent and incident cases is important; among the larger pool of prevalent cases existing studies have selected patients in randomised trials3 or undergoing coronary angiography.4 There are few population based studies that have assessed the impact of SES on case fatality in prevalent CHD; this is important in targeting preventive or treatment strategies as well as in identifying mechanisms mediating the effect of SES on CHD risk.

Defining prevalent cases of CHD is, however, problematic. Angina is more prevalent than myocardial infarction,6 yet unlike myocardial infarction, it lacks an internationally agreed definition that combines subjective and objective criteria. SES may affect the reporting and perception of symptoms,7 access to medical care, diagnosis, treatment and outcome.8 9 By contrast, asymptomatic manifestations of coronary disease are not prone to these effects. In epidemiological studies the electrocardiogram (ECG) is the only widely used tool to investigate asymptomatic changes associated with CHD for which long term mortality follow up data are available. Recent studies suggest that asymptomatic ST-T changes may be valid markers of pre-clinical CHD as they predict CHD mortality, independent of other risk factors.10-12 This suggests the potential value of CHD case definitions using specific ECG abnormalities separately in those with and without symptoms.

No previous study has investigated the relation between SES, symptomatic status, ECG abnormalities and CHD events. The objective, therefore, was to compare the impact of SES on CHD mortality in people with and without prevalent CHD at baseline. The original Whitehall cohort study offers the advantages of a relatively precise measure of SES, civil service employment grade, and a large number of events during 25 years of follow up.13

Method

PARTICIPANTS

Details of the original Whitehall study have been reported elsewhere.14 A total of 19 019 non-industrial male civil servants aged 40–69 years who were working in London attended the original screening examination between September 1967 and January 1970. The response rate was 74%.

SOCIOECONOMIC STATUS

The civil service grade of employment was used to define SES in four categories (in order of descending SES): administrative, professional or executive, clerical and other grades. These grades reflect salary, education and work responsibility and their monotonic inverse relation with CHD mortality, independent of conventional risk factors, has been demonstrated.13 15 For 886 men from the diplomatic service and the British Council employment grading was not comparable. These men have been removed from all analyses.

CASE DEFINITIONS OF PREVALENT CHD

Prevalent CHD was defined by specific ECG abnormalities or symptoms or both. Electrocardiography was undertaken with a Mingograph 31B, using “multipoint” electrodes.16 Five technically adequate complexes were recorded for each of the six limb leads and the middle three complexes were later analysed according to the Minnesota code.17 The six limb lead ECG removed the need for participants to undress. Coding was carried out independently in duplicate by trained and tested technicians.18 Q (Minnesota codes 1:1–1:3), ST (4:1–4:3) and T (5:1–5:3) abnormalities were chosen for defining CHD, since these are the strongest independent predictors of CHD events. Participants were defined as symptomatic if they reported angina,19prolonged chest pain (“pain of possible myocardial infarction”) or a previous admission to hospital for CHD. Participants who responded positively to the question “under the general practitioner with heart disease or blood pressure?” were also included in the symptomatic group for two reasons. Firstly, this group had higher age adjusted hazard ratios for CHD mortality than those reporting Rose angina or possible myocardial infarction alone (hazard ratios 3.56, 2.70 and 2.07 respectively). Secondly, adjustment for the use of anti-hypertensive medication, systolic and diastolic blood pressure had little effect on the hazard ratio (decreasing to 3.20), suggesting the greater importance of the “heart disease” than the “blood pressure” component of this group.

CHD RISK FACTORS

The baseline questionnaire obtained details of smoking history. With the participant seated, a single reading of blood pressure was recorded on the left arm by specially trained observers using the London School of Hygiene random zero sphygmomanometer. Plasma cholesterol, fasting and two hour post-load glucose, height, weight and forced expiratory volume in one second (FEV1), were determined in standardised fashion.

MORTALITY

Records from 99.3% of the participants, were identified and flagged at the National Health Service Central Registry who notified us of all deaths up to the end of January 1995 and provided a copy of the death certificate. After exclusion of a further 94 men with unknown symptomatic status, a total of 17 907 men with mortality follow up were available for analysis. These men have been followed up for a minimum of 25 years, during which time there have been 8005 deaths. Death certificates were coded by the Office of Population Censuses and Surveys, according to the eighth Revision of the International Classification of Diseases. Coronary heart disease was defined by ICD-8 codes 410–414.

STATISTICAL METHODS

Age adjusted mortality rates, means and proportions were calculated by direct standardisation using the total Whitehall study population as the standard. For continuous variables, tests of heterogeneity in means were assessed by the significance of the ECG groups fitted as a factor in linear regression models with age group as a covariate. For dichotomous variables, the tests of heterogeneity of proportions were assessed using Cochran-Mantel-Haenszel tests of association with the ECG groups stratified by age group. Adjusted mortality hazard ratios and their confidence intervals were estimated using Cox's proportional hazards regression models. The relations of employment grade both to CHD mortality and the prevalence of ECG abnormalities were linear. Odds ratios for the prevalence of ECG abnormalities in the lowest compares with highest grades were therefore estimated using logistic regression from a linear trend term across grades. This method provides a more precise estimate of the grade effect than just comparing the two extreme grades. The effects of grade on CHD mortality were similarly estimated using a linear trend term for grade in proportional hazards models. All analyses were performed using the statistical package SAS.20

Results

key points
  • Few population-based studies have compared the inverse association between socioeconomic status (SES) and coronary heart disease (CHD) mortality separately among people with and without prevalent CHD

  • In this study of more than 17 000 male civil servants, 31% of CHD deaths occurred in those with prevalent CHD at baseline based on symptoms or Q, ST or T wave electrocardiographic abnormalities

  • The inverse SES-CHD mortality relation was seen in those with and without prevalent CHD

  • Further investigation of the relative contribution of SES to the initiation and progression of CHD requires repeated measures studies of pre-clinical and clinical measures of CHD

There were monotonic inverse associations between employment grade and age adjusted prevalence of CHD symptoms and CHD mortality (p for linear trend across grade <0.001, table 1). The age adjusted odds ratios for the lowest versus highest grade for CHD symptoms was 1.53 (95%CI 1.2, 1.9). The age adjusted hazard ratio for CHD mortality for the lowest versus highest employment grade was 1.56 (95% CI 1.2, 2.1).

Table 1

Employment grade differences in age and age adjusted prevalence of CHD symptoms at baseline and CHD mortality rates over 25 years

Table 2 shows the effect of the presence compared with the absence of each specific ECG abnormality on all cause and coronary mortality by symptomatic status. Most of the ECG abnormalities were associated with an age adjusted increase in risk of mortality in both symptomatic and, to a lesser extent, asymptomatic participants. Most of the abnormalities were more prevalent among symptomatic participants. However, among asymptomatic participants, effects on CHD with hazard ratios >2 were found for ST depression (> 0 mm and < 1 mm, hazard ratio 2.26 (95% CI 1.6, 3.2)), T wave inversion ( ⩾1mm, hazard ratio 2.20 (95% CI 1.5, 3.3)) and atrial fibrillation (hazard ratio 3.22 (95% CI 1.8, 5.7)). The numbers of participants with right axis deviation (n=2, code 2:2 ), third degree heart block (n=0, code 6:1), second degree heart block (n=3, code 6:2) and Wolf Parkinson White syndrome (n=4, code 6:4) were too low to permit mortality analyses.

Table 2

ECG abnormalities: age adjusted prevalence and age adjusted hazard ratios2-150 (95% confidence intervals) for their effect on all cause and coronary mortality by symptomatic status

The validity of the case definitions of prevalent CHD was investigated by examining associations cross sectionally with CHD risk factors (table 3) and longitudinally with CHD mortality (table 4).

Table 3

Age adjusted prevalence or means of risk factors in participants with Q, ST or T wave abnormalities alone or in combination, by symptomatic status

Table 4

Effects of Q, ST, and T wave abnormalities alone or in combination on CHD mortality, by symptomatic status. Effects are given as hazard ratios (95% CI) adjusted separately for age and age + systolic and diastolic blood pressure

Table 3 shows the associations of Q (1:1–1:3), ST (4:1–4:3) and T (5:1–5:3) abnormalities alone (in order to distinguish the effect of different Minnesota codes coexisting on the same ECG) or in combination, on CHD risk factors. There were five combinations of abnormality (no participants had Q and T abnormalities only and three participants had only ST abnormalities). The presence of ECG abnormalities was most strongly associated with increasing age and higher systolic blood pressure and diastolic blood pressure.

The effects of these five combinations of ECG abnormality on CHD mortality separately adjusted for age and age + systolic + diastolic blood pressure are shown in table 4. Asymptomatic individuals without any QT, ST or T abnormalities were used as the comparison group for all the analyses in table 4. Among asymptomatic participants, the hazard of CHD death was progressively greater among those with one, two and three abnormalities of the Q, ST, and T waves (p for trend <0.001). Among those with symptoms, each of the five combinations was more prevalent than among those without symptoms; and the relative effect on mortality was greater. Sixty nine per cent (1852 of 2695) of the CHD deaths occurred in those without either symptoms or Q, ST or T abnormalities.

So called “minor” T wave abnormalities (zero, negative or diphasic T waves, 5:3) were associated with risk of CHD, in the absence of ST or other abnormalities, with hazard ratios of 1.58 (95%CI 1.3, 2.0) and 2.06 (95%CI 1.6, 2.7) in asymptomatic and symptomatic participants respectively. The 4:4 code was removed because of small numbers and lack of effect on CHD mortality.

Employment grade was associated with the prevalence of any Q, ST and T wave abnormality among symptomatic participants. The odds ratio for the prevalence of any such abnormality in people with symptoms for the lowest versus highest grade was 1.77 (95% CI 1.1, 2.7)), an effect explained by Q only, T only and Q + ST abnormality. Employment grade was not associated with the prevalence of Q, ST and T wave abnormality among asymptomatic participants (odds ratio of the prevalence of any Q, ST or T abnormality for the lowest versus highest grade was 1.12 (95% CI 0.8, 1.5)). There was an inverse association of atrial fibrillation and low QRS amplitude with grade among asymptomatic participants; none of the other ECG abnormalities was associated with grade (data not shown).

Table 5 shows that CHD mortality was inversely associated with employment grade in people with no Q, ST or T abnormality in asymptomatic and symptomatic participants (hazard ratios 1.81 (95% CI 1.5, 2.2) and 1.52 (95% CI 1.1, 2.1) respectively). In the presence of any of these ECG abnormalities, the inverse association of employment grade with CHD was not statistically significant. Although the point estimates among those with any Q, ST or T abnormality were lower than those without, the p values for these differences were >0.3. Additional adjustment for systolic and diastolic blood pressure had little effect on any of these estimates. For all cause mortality, the findings in relation to employment grade and ECG abnormality were similar to those for CHD mortality.

Table 5

Effect of low compared with high employment grade on CHD mortality by ECG abnormality and symptomatic status. Effects are given as hazard ratios (95% CI) adjusted separately for age and age + systolic + diastolic blood pressure

Discussion

In a prospective study of over 17 000 civil servants followed up for 25 years, there was an inverse association between SES and CHD mortality in participants with and without prevalent CHD at baseline.

The inverse social gradient in CHD mortality could be a result of increased incidence (aetiology), case fatality (prognosis) or both among those of lower SES. Case fatality includes both survival of an acute event, such as myocardial infarction, and prognosis in chronic manifestations of CHD, such as angina. We studied the latter—established CHD in a working population— and found a significant effect of SES on CHD mortality among those with prevalent CHD defined by symptomatic status. When prevalent CHD was defined by Q, ST or T abnormality in the absence of symptoms, the SES effect was similar but the confidence intervals spanned unity. Participants with both symptoms and ECG abnormality were at very high risk (relative to those without symptoms or any ECG abnormality) and in this group there was little evidence of SES effect. This is consistent with a diminution of influence of SES in the face of such competing risks.

Over 25 year follow up there were 843 CHD deaths (nearly one third of all CHD deaths) in participants with CHD at baseline. Despite this large number of events overall, there was a relatively small number of CHD events occurring among participants with prevalent ECG abnormality in the absence of symptoms, raising the possibility of type II error.

The main limitation of this study is that cases of CHD were defined cross sectionally at baseline. It is not known whether people who were asymptomatic and without ECG abnormality at baseline became cases before CHD death. We examined case fatality in an employed population sample of prevalent cases of CHD, in which survival of acute manifestations of CHD may already have been influenced by grade. This problem can only partly be surmounted by studying incident non-fatal myocardial infarction, where the timing and newness of the event are readily defined. By contrast, defining the stage at which a person becomes a pre-clinical case of CHD or a case of angina is less straightforward. There is a growing recognition that pre-clinical abnormalities of vascular structure and function are present in early life,21 develop through mid-life and precede the onset of the range of clinical manifestations of CHD. Therefore, to elucidate further the relative contribution of incidence and case fatality to the social gradient in coronary disease, longitudinal repeated measures studies are required that examine the effect of SES on the development over time of interrelations between pathophysiology, symptoms, becoming a case, case severity and the impact of medical care. In the absence of direct measures of coronary artery pathophysiology suitable for use in epidemiological studies, carotid intima-media thickness is proving a valid tool for investigating SES effects on pre-clinical and clinical disease.22-24

We defined a prevalent case of CHD as having electrocardiographic abnormality (of Q, ST or T wave), symptoms (defined by the Rose chest pain questionnaire and self reported doctor diagnosis) or both. The validity of these case definitions was supported by their associations with CHD risk factors and with CHD mortality. As ST and T wave changes might reflect effects of blood pressure as well as ischaemia we adjusted for systolic and diastolic blood pressure; the generally small effects of such adjustments support the electrocardiographic measures as markers of ischaemia. Furthermore, consistent with other studies,10-12 flat, negative or diphasic T waves were associated with CHD mortality even in those without symptoms (such changes should not therefore be called “minor or mild”) and in those without symptoms there was a linear association between the number of ECG abnormalities (0,1,2) and subsequent CHD mortality.

In the context of epidemiological study the ECG remains the only non-invasive means of defining pre-clinical early cardiac abnormality for which long term mortality follow up data are available. This allowed examination of specific causal mechanisms (putative role of ST segment) and potential sources of bias (for example, reporting bias) to be investigated. While the resting ECG is valid in defining CHD,25 two observations suggest that qualitative (present/absent) measures of ECG abnormality using the Minnesota code in the six limb lead ECG may not be sufficient to investigate SES-CHD mechanisms. Firstly, there was no evidence that SES was associated with pre-clinical disease indicated by the presence of Q, ST or T abnormalities amongst those without symptoms. Secondly, a specific effect of SES on the ST segment might have been anticipated as the ST segment is influenced by psychosocial stressors,26-31which themselves have been proposed as mediators of the SES-CHD relation.32-34 We found no evidence that employment grade was related to resting ECG ST-T wave abnormalities. However, six limb lead ECGs underestimate the true prevalence of ST and other abnormalities found in the chest leads (V1-V6), which are available only on a 12 lead ECG. Quantitative ECG measures from the ECG, for example of parasympathetic:sympathetic balance using heart rate variability, may prove more promising tools for the investigation of the SES-CHD relation.35 36

A further reason why prevalent CHD was defined separately in those with and without symptoms was because SES may affect the reporting of symptoms. Barsky has proposed that in “silent ischaemia” it is the patient rather than the ECG who is silent and therefore SES may affect symptom perception, attribution and denial as well as visceral and central pain mechanisms.7 The data presented here argue against an important reporting bias by SES, as grade was both inversely associated with reporting symptoms and with CHD mortality separately in those with and without symptoms.

As policy interest in tackling social inequalities in health has been renewed,37 38 what are the implications of these findings for prevention or treatment? In absolute terms—important for public health—measures that reduce social differences in coronary risk before people develop ECG changes or symptoms will have the greatest impact. Such measures might include changes at the population or individual level in income distribution, health behaviours and the psychosocial environment. Inferences about the impact of medical care on the SES-CHD relation cannot be made from the data presented here. Among people with symptoms, who are more likely to be under medical care, the point estimates for the effect of SES on CHD mortality were smaller than for those without, although the respective 95% confidence intervals overlapped. This observation is equally consistent both with an effect of medical care in mitigating the impact of SES or in SES having a lesser effect in cases compared with non-cases, regardless of medical care. This issue has rarely been studied, although it is worth noting that in the stepped care arm of the Hypertension Detection and Follow Up Programme, education differences in mortality were abolished.39

In summary, SES measured by employment grade was inversely associated with CHD mortality in civil servants with and without prevalent CHD at baseline. The effects among prevalent cases depended on the definition of CHD: they were significant for participants who were symptomatic only; consistent but not significant for ECG abnormality only and were lacking in the highest risk group with both symptoms and ECG abnormality. Distinguishing the relative contribution of SES to the initiation and progression of CHD requires repeated measures studies of pre-clinical and clinical measures of CHD.

References

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Footnotes

  • Funding: MM is supported by an MRC Research Professorship. MS is supported by the British Heart Foundation.

  • Conflicts of interest: none

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