A method of implementing the anti-D prophylaxis programme is described and its efficiency is studied by examination of the records of 889 Rhesus-negative mothers. During one calendar year only eight (0·9%) cases were found where there was failure to follow the correct procedure and to administer anti-D. Sixty-two point five per cent of the mothers who were given anti-D received it within 24 hours and all but 3% within 48 hours. Methods of improving the programme are discussed.
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