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Perineal use of talc and risk of ovarian cancer

¹ The Cancer Registry of Norway, Institute of population-based Cancer Research, Oslo, Norway
² Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA
³ Department of Social and Preventive Medicine, University of Montreal, Montreal, Canada
⁴ Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
⁵ Samfundet Folkhälsan, Helsinki, Finland

Correspondence to:
E Weiderpass, The Cancer Registry of Norway, 0310 Oslo, Norway; eliwei{at}ki.se

Ovarian cancer is one of the most common gynaecological neoplasms, especially in industrialised countries. The aetiology of the disease is not well understood, except that inherited mutations in the breast cancer genes BRCA-1 and BRCA-2 account for up to 10% of all cases,¹ and child-bearing, oral contraceptive use and breast-feeding reduce the risk.² Some environmental exposures, notably talc and asbestos, have been suspected as ovarian carcinogens.